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App note: Mass photometry for the study of PROTAC ternary complexes
Learn how mass photometry can be used to inform on aspects of PROTAC ternary complex formation in solution, without requiring protein labelling or immobilization. These aspects involve a range of behaviors important for PROTAC mechanistic function: ternary complex formation, cooperativity, stoichiometry, and hook effect. Discover how you can apply mass photometry to visualize the possible intermediate interactions, due to cooperative effects, in a three-part PROTAC system. The system presented in the application note includes the target protein BRD4 (implicated in the development of several cancers), the VHL/ElonginC/ElonginB ligase and the PROTAC compound MZ1.
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Exploring the structural dynamics of shelterin with mass photometry
In this webinar, Svea Cheeseman, Director of Product Management for Cell and Gene Therapy at Refeyn, discusses how mass photometry can be used to characterize AAV capsids – by measuring the empty/full capsid ratio for AAVs of any serotype with low sample consumption. She also introduces the SamuxMP Auto, Refeyn’s automated mass photometer.
The evolution of carbon fixation: Studying Form I Rubisco using ancestral sequence reconstruction and mass photometry
Discover how mass photometry can be used in combination with ancestral sequence reconstruction to determine when an ancestral enzyme gained its structural complexity and how it started to interact with a novel subunit.
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Find out how mass photometry can transform your sample characterization. Whether you’re focused on drug development, discovery science, or manufacturing, Refeyn’s innovative technology provides the insights you need to accelerate your breakthroughs.