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App note: Mass photometry for the study of PROTAC ternary complexes

Learn how mass photometry can be used to inform on aspects of PROTAC ternary complex formation in solution, without requiring protein labelling or immobilization. These aspects involve a range of behaviors important for PROTAC mechanistic function: ternary complex formation, cooperativity, stoichiometry, and hook effect. Discover how you can apply mass photometry to visualize the possible intermediate interactions, due to cooperative effects, in a three-part PROTAC system. The system presented in the application note includes the target protein BRD4 (implicated in the development of several cancers), the VHL/ElonginC/ElonginB ligase and the PROTAC compound MZ1.

Cover of app note PROTAC

Additional resources

BLOG​: Exploring the structural dynamics of shelterin with mass photometry

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WEBINAR​: The evolution of carbon fixation: Studying Form I Rubisco using ancestral sequence reconstruction and mass photometry

Discover how mass photometry can be used in combination with ancestral sequence reconstruction to determine when an ancestral enzyme gained its structural complexity and how it started to interact with a novel subunit.

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