Thank you for your interest in Refeyn’s mass photometry technology

Learn how mass photometry can be used to inform on aspects of PROTAC ternary complex formation in solution, without requiring protein labelling or immobilization. These aspects involve a range of behaviors important for PROTAC mechanistic function: ternary complex formation, cooperativity, stoichiometry, and hook effect. Discover how you can apply mass photometry to visualize the possible intermediate interactions, due to cooperative effects, in a three-part PROTAC system. The system presented in the application note includes the target protein BRD4 (implicated in the development of several cancers), the VHL/ElonginC/ElonginB ligase and the PROTAC compound MZ1.