mRNA technologies are rapidly reshaping modern medicine, but understanding the structural integrity of mRNA products remains a major challenge. Throughout development and manufacturing, impurities such as dsRNA, truncated transcripts, and multimers can impact efficacy and safety—yet many analytical tools rely on denaturing conditions that miss these native‑state features.

In this webinar, Professor Mark Dickman (University of Sheffield) demonstrates how combining non‑denaturing IP‑RP‑HPLC with mass photometry enables precise, label‑free measurement of mRNA monomers and multimers in solution.

Key Takeaways:

• Understand key quality attributes influencing mRNA safety and performance
• Explore analytical challenges in assessing integrity, purity, and structure
• Learn how IP‑RP‑HPLC + mass photometry enables native‑state mRNA characterization