Mass photometry applications

Mass photometry technologies are a recent addition to the bioanalytical toolkit. By directly measuring molecular mass in solution, mass photometry reports on fundamental properties of the sample while maintaining a native environment. It is applicable to a wide range of different molecules and can be used in basic research, drug discovery and manufacturing. The related technology, macro mass photometry, analyzes vectors, such as lentivirus and adenovirus, directly in solution.

Mass photometry measures mass at the single molecule level, providing insights into the composition and function of even complex samples and molecular mechanisms. This unique technology can detect and characterize proteins, nucleic acids, adeno-associated viruses (AAVs), lipids and sugars. It provides information on oligomeric state and stoichiometry, sample homogeneity, molecular interactions, capsid loading, and aggregation and degradation – all in a matter of minutes and using tiny amounts of sample.

Due to its unique benefits, mass photometry technologies address a major unmet need for more efficient analytical tools. With over 500 scientific papers citing mass photometry, it is helping accelerate science, and the discovery and development of new therapeutics.