The SamuxMP Auto is the automated mass photometer for AAV characterization, autonomously measuring up to 24 samples in approximately 90 minutes. The instrument rapidly measures AAV empty/full ratios, sample purity and particle aggregation for any AAV serotype – with high precision and reproducibility.
Rapid characterization of empty/full AAV capsid ratio
Automated technology – 24 measurements in about 90 min
Highly reproducible data with minimal sample preparation
Automation unit retrofittable to the SamuxMP
Empty/full AAV capsid ratio
Partially filled and overfilled capsids
Detection of aggregates and impurities
Rough titer estimation
24 measurements in about 90 min
High reproducibility
Automation unit retrofittable to the SamuxMP
Benchtop instrument
Minimal sample preparation
Minimal training required
The SamuxMP Auto offers all the advantages of AAV capsid analysis with mass photometry while adding convenience and reproducibility via automated, highly consistent sample manipulation (Fig. 1). It accurately measures empty/full capsid ratios of AAVs, and detects partially filled and overfilled AAVs in heterogeneous samples.
The SamuxMP Auto can autonomously analyze 24 samples in as little as 90 minutes, yet fits on a benchtop. Its integrated software suite allows the user to define measurement protocols, analyzes the 24 measurements on the fly, and makes it easy to plot and export the resulting data in a variety of formats.
The robotics unit can be retrofitted to existing SamuxMP instruments.
Software solution expands the use of the SamuxMP and the SamuxMP Auto mass photometers to GMP – regulated environments and enables their use within AAV-based gene therapy manufacturing pipelines.
The software package supports compliance with the FDA 21 CFR 11 (US) and EU GMP Annex 11 regulations. It includes three applications: ManageMP, AcquireMP and EvaluateMPS. The Refeyn service teams also provide installation and operational qualifications (IQ/OQ), as well as documentation and on-site training.
It can measure 24 samples autonomously including calibrants. After 24 samples, the glass sample carrier slide must be exchanged manually.
Yes, it can do dilutions in the 96-well plate. Dilutions are limited to factors that are multiples of 10.
Yes, we recommend running a calibrant as the first and last sample on every 24-well slide. This will ensure the highest mass accuracy and serve as an internal control. We recommend performing a 1-point calibration with empty AAV capsids of known mass.
A software package compliant with FDA and EU GMP Annex 11 regulations is available for use with the SamuxMP and SamuxMP Auto. In addition, the Refeyn service teams provide installation and operational qualifications (IQ/OQ) for instruments destined to GMP-regulated environments.
In this webinar, Svea Cheeseman, Director of Product Management for Cell & Gene Therapy at Refeyn, discusses how mass photometry can be used to characterize AAV capsids – by measuring the empty/full capsid ratio for AAVs of any serotype with low sample consumption. She also introduces the SamuxMP Auto, Refeyn’s automated mass photometer for rapid and autonomous analysis of AAV samples.
In this webinar, James Walkinson gives an overview of how mass photometry works and present the SamuxMP product line, which is tailored for the analysis of AAVs. James provides benchmarking data to compare mass photometry with other technologies that are gold standards for AAV characterization, and presents case studies showing the performance of the SamuxMP and SamuxMP Auto mass photometers.
Top up your supply of consumables for analyzing AAV samples with the SamuxMP and SamuxMP Auto mass photometers. Refeyn’s consumables are recommended to ensure consistent measurements.
Purchase the sample preparation packs which include sample carrier slides and sample cassettes with 6 or 24 wells. Order MassFerence P2, a calibrant tailored for AAV analytics with the Samux mass photometers. Click below to learn more.
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