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Featured Publications

Check out all the newest publications, reviews, and articles featuring mass photometry. Use the filters to find specific application areas, biomolecule types, and more.

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May 14, 2024

The mutation R107Q alters mtSSB ssDNA compaction ability and binding dynamics

Nucleic Acids Research (2024)

Martucci, M., Moretton, A., Tarrés-Solé, A., Ropars, V., Lambert, L., Vernet, P., Solà, M., Falkenberg, M., Farge, G., van den Wildenberg, S.

Keywords:

protein-nucleic acid interactions, ssDNA, protein interaction, mutations, mitochondrial DNA, protein oligomerization, protein interactions

May 14, 2024

Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes

Nature Biotechnology (2024)

Wu, T., Yu, J.C., Suresh, A., Gale-Day, Z.J., Alteen, M.G., Woo, A.S., Millbern, Z., Johnson, O.T., Carroll, E.C., Partch, C.L., Fourches, D., Vinueza, N.R., Vocadlo, D.J., & Gestwicki, J.E.

Keywords:

Assay systems, Biophysical methods, Chemical libraries, High-throughput screening, protein interactions

May 13, 2024

Polymerization mechanism of the Candida albicans virulence factor candidalysin

Journal of Biological Chemistry (2024)

Schaefer, K.G., Russell, C.M., Pyron, R.J., Conley, E.A., Barrera, F.N., King, G.M.

Keywords:

candidiasis, Candida albicans, therapeutics, complex formations, protein oligomerization, protein interactions

May 8, 2024

Label-free detection and profiling of individual solution-phase molecules

Nature (2024)

Needham, L., Saavedra, C., Rasch, J.K., Sole-Barber, D., Schweitzer, B.S., Fairhall, A.J., Vollbrecht, C.H., Wan, S., Podorova, Y., Bergsten, A.J., Mehlenbacher, B., Zhang, Z., Tenbrake, L., Saimi, J., Kneely, L., Kirkwood, J.S., Pfeifer, H., Chapman, E.R., & Goldsmith, R.H.

Keywords:

Biophotonics, Biophysical methods, Characterization and analytical techniques, Microresonators, Optical sensors

May 6, 2024

A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3KLHL22

Nature Communications (2024)

Wang, W., Liang, L., Dai, Z., Zuo, P., Yu, S., Lu, Y., Ding, D., Chen, H., Shan, H., Jin, Y., Mao, Y. & Yin, Y.

Keywords:

Cryoelectron microscopy, Ubiquitylation, E3 ligases, complex formation, protein oligomerization, protein interactions, enzyme regulation, enzyme activity

Dec 13, 2023

Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1

Nature Structural and Molecular Biology (2024)

Duering, J., Wolter, M., Toplak, J., Torres, C., Dybkov, O., Fokkens, T., Bohnsack, K., Urlaub, H., Steinchen, W., Dienemann, C., Lorenz, S.

Keywords:

E3, enzyme mechanism, RAC1, cryo-EM, SAXS, hydrogen-deuterium exchange mass spectrometry, crosslinking

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