2023 MERCK Technology Symposium
This year’s 26th Annual Merck Technology Symposium will be organized around several tracks illustrating the various ways that technologies are facilitating scientific decision-making at Merck
Higher Order Structure 2023 (HOS CASSS)
The higher-order structure (HOS) and dynamics of proteins are essential for their function. This is the premise of HOS 2023. For protein-based therapeutic products, HOS is a critical quality attribute that must be monitored to ensure the safety and efficacy of the drug products.
Harnessing mass photometry for AAV sample characterization in GMP-regulated environments
This webinar, will explain how the new, compliant software solutions address all regulatory requirements, including user management, audit trails, and signing options when exporting files from Refeyn software applications. The new software solutions will be compatible with the SamuxMP and SamuxMP Auto mass photometers, which are optimized for AAV analytics. This allows the ability to […]
Navigating The Complexities of AAV Scale Up to Keep Pace with the Increasing Demand For these Viral Vector Delivery Systems
In this webinar you will learn about the presence of inactive, empty capsids in potentially large quantities is one of the main challenges in AAV production. Quantifying the ratio of empty / full AAV capsids is currently challenging – existing methods are not quick and simple enough to be employed throughout the process.
Architecture and Stoichiometry of Human Shelterin Using Single-Particle EM and Mass Analysis
In this webinar, Dr. John Zinder, a Senior Scientist in the Structural Biology group at Odyssey Therapeutics, will discuss the purification of shelterin subcomplexes and reconstitution of the entire complex using full-length, recombinant subunits. By combining mass photometry, negative-stain electron microscopy (EM), crosslinking mass spectrometry (XLMS), AlphaFold modelling, and native mass spectrometry (MS), stoichiometries were […]
Webinar | Monitoring Aggregation Levels of Biosimilar mAbs Using Mass Photometry and SEC
In the presented analysis, both SEC and mass photometry were used to measure aggregation levels. The results of this short study demonstrate that SEC and mass photometry are complementary, highlighting the usefulness of mass photometry as an orthogonal technique for monitoring aggregation of biopharmaceuticals such as mAbs.
Webinar | Assessing AAV production variability with single-particle mass analysis
This webcast will demonstrate how the mass of AAV capsids can be determined using two different novel, emerging single-particle techniques: charge-detection mass spectrometry (CDMS) and mass photometry. In contrast to ensemble-based approaches (e.g., native mass spectrometry), mass photometry and CDMS can measure the mass of numerous, individual AAV particles, circumventing issues driven by sample heterogeneity.
Webinar | Studying protein polymerization with mass photometry
Protein polymerization underpins major biological processes, such as cell division and intracellular transport, while undesired assembly can lead to protein aggregates that are associated with, for example, neurodegenerative diseases and cancer.
Mass photometry Symposium And User Meeting
This in-person meeting brings together mass photometry users working across different applications including biomolecular and AAV analytics. This exclusive event will include scientific talks by the mass photometry user community, and announcement of 2023 innovations by Refeyn experts.
Webinar | Demonstrating Analytical Comparability in Analytical Development
The webinar will focus on challenges in analytical comparability for gene therapy products. In addition, orthogonal methods along with some of the common statistical analyses will be discussed.
