Integrative structural biology is a powerful approach to understand biological macromolecular systems. By combining computational methods with structural science disciplines, spatial and temporal models of macromolecular targets in their in-situ context can be determined.
Meeting on the MESA is focused on the exciting world of cell and gene therapy. Professionals from various industries gather to discuss the latest advancements in developing cell and gene therapies. The goal is to accelerate progress and innovation.
This meeting brings together an emerging community of scientists from analytical, preparative, and native mass spectrometry, molecular electron microscopy and scanning probe microscopy to explore the possibilities and challenges of novel approaches for single-molecule imaging.
This year’s 26th Annual Merck Technology Symposium will be organized around several tracks illustrating the various ways that technologies are facilitating scientific decision-making at Merck
The higher-order structure (HOS) and dynamics of proteins are essential for their function. This is the premise of HOS 2023. For protein-based therapeutic products, HOS is a critical quality attribute that must be monitored to ensure the safety and efficacy of the drug products.
This webinar, will explain how the new, compliant software solutions address all regulatory requirements, including user management, audit trails, and signing options when exporting files from Refeyn software applications. The new software solutions will be compatible with the SamuxMP and SamuxMP Auto mass photometers, which are optimized for AAV analytics. This allows the ability to […]
In this webinar you will learn about the presence of inactive, empty capsids in potentially large quantities is one of the main challenges in AAV production. Quantifying the ratio of empty / full AAV capsids is currently challenging – existing methods are not quick and simple enough to be employed throughout the process.
In this webinar, Dr. John Zinder, a Senior Scientist in the Structural Biology group at Odyssey Therapeutics, will discuss the purification of shelterin subcomplexes and reconstitution of the entire complex using full-length, recombinant subunits. By combining mass photometry, negative-stain electron microscopy (EM), crosslinking mass spectrometry (XLMS), AlphaFold modelling, and native mass spectrometry (MS), stoichiometries were […]
In the presented analysis, both SEC and mass photometry were used to measure aggregation levels. The results of this short study demonstrate that SEC and mass photometry are complementary, highlighting the usefulness of mass photometry as an orthogonal technique for monitoring aggregation of biopharmaceuticals such as mAbs.
This webcast will demonstrate how the mass of AAV capsids can be determined using two different novel, emerging single-particle techniques: charge-detection mass spectrometry (CDMS) and mass photometry. In contrast to ensemble-based approaches (e.g., native mass spectrometry), mass photometry and CDMS can measure the mass of numerous, individual AAV particles, circumventing issues driven by sample heterogeneity.
