Revolutionizing AAV analytics with mass photometry

Mass photometry measures the mass of single particles in solution without disruptive preparation or labels. This powerful simplicity makes it a versatile technique, with a role to play in a variety of applications, from assessing antibody aggregation to measuring RNA length. Among these, characterizing AAVs is one where mass photometry really shines and is quickly being adopted across pharmaceutical companies and CROs.

Developing an AAV production pipeline and scaling it up to manufacture safe and effective pharmaceuticals is far from straightforward. Across AAV development and production, critical quality attributes (CQAs) of the samples need to be accurately assessed without bogging down the process. Let’s take a detailed look at these CQAs, the current analytical challenges faced by AAV development and production, and how mass photometry addresses them with efficient, in-line AAV sample characterization.