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Tech note: Quantifying antibody aggregation with the mass photometry Antibody Stability Module
In this technical note, you will see how to use mass photometry and the Antibody Stability Module to quickly detect and quantify antibody aggregation. The tech note also shows how mass photometry can measure antibody aggregation at both nanomolar and micromolar concentrations.
To demonstrate the application of mass photometry measurements, this tech note shows measurements of commercial antibody samples, as well as the results of a forced degradation study.
Additional resources
TECH NOTE: Mass photometry a column-free orthogonal to SEC-UV
This tech note shows how aggregation is an important quality attribute of many protein-based biopharmaceuticals, including monoclonal antibodies (mAbs) and multi-specific antibodies, which can influence product efficacy and safety. Monitoring of aggregation levels is therefore essential.
WEBINAR: Rapid analytical approach for biologics characterization
In this webinar you will learn – via example data and case studies – how mass photometry supports the development and production of therapeutic biologics such as antibodies and AAVs. Mass photometry is a powerful bioanalytical tool that characterizes samples at the single-molecule level with low sample consumption, fast turnaround times and no need for labels. These strengths make mass photometry an ideal technique to characterize key analytical attributes of therapeutic biologics at different stages of development and production.
