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Application note: Mass photometry analysis of GPCRs in copolymer nanodiscs

In this application note, created in collaboration with CUBE Biotech, copolymer-derived nanodiscs were used to solubilize GPCRs. The embedded proteins were fractionated using SEC, then characterized with SDS-PAGE, western blot, DLS and mass photometry. 
 

Discover how to use mass photometry to expedite functional assays or structural investigations by obtaining detailed information on your membrane protein samples or SEC fractions. Learn how copolymer-derived nanodiscs can be used for GPCR solubilization, and how mass photometry compares to other techniques in this context.  

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Additional resources on mass photometry analysis of membrane proteins

WEBINAR​: Investigating membrane protein complexes with mass photometry

This webinar shows the applications of mass photometry for the study of two examples of macromolecular complexes formed by eukaryotic membrane proteins. In both cases, mass photometry was crucial to addressing highly relevant physiological questions. The webinar showcases what value can mass photometry deliver, and what makes it suitable for studies of membrane protein complexes. 

webinar-Investigating-membrane-protein-complexes-with-mass-photometry
Blog

BLOG: How to study membrane proteins with mass photometry

Mass photometry provides valuable information on the purity and behavior of samples containing membrane proteins and membrane mimetics. In this blog post, we examine the role of mass photometry in membrane protein analysis and describe case studies that illustrate how mass photometry is contributing to the field. 

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