Application Area: Interaction/Binding

Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity

Structural insights into IMP2 dimerization and RNA binding

Polymerization mechanism of the Candida albicans virulence factor candidalysin

Engineering CRBN for rapid identification of next generation binders

Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization

Perturbation of the host cell Ca2+ homeostasis and ER-mitochondria contact sites by the SARS-CoV-2 structural proteins E and M

The Phosphatase PP2A Interacts With ArnA and ArnB to Regulate the Oligomeric State and the Stability of the ArnA/B Complex

Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses

Oligomeric Remodeling by Molecular Glues Revealed Using Native Mass Spectrometry and Mass Photometry

Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2