Assessing AAV stability with mass photometry: Striking insights into the outcomes of heated capsids

Presenter: Eduard Ebberink

Home / Resources / Webinar: Assessing AAV thermal stability 

In this webinar, Eduard Ebberink talks about using mass photometry to assess capsid stability after heating different empty and filled AAV preparations. Watch now to learn how mass photometry can be used to determine how different serotypes, genomes and host systems impact the thermal uncoating process.  

Mass photometry in combination with nuclease treatment can be used as an analytical tool for assessing the structural integrity of recombinant and/or clinical AAV vectors. Watch this webinar to learn:  

  • How the thermal uncoating process varies distinctly among different AAV preparations  
  • Why empty AAV capsids are more heat-stable than genome-filled AAVs 
  • How mass photometry allows for fast AAV quantification and custom-made, in-solution assays 

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