ON-DEMAND WEBINAR
Advancements in Protein Design Shaping the Future of Nanodevices
Presenter: Dr. Arvind Pillai
Postdoctoral Fellow in the lab of 2024 Nobel Laureate David Baker
Institute for Protein Design, University of Washington
In this webinar, explore innovations in protein design with Dr. Arvind Pillai. Learn how switchable protein assemblies pave the way for new nanomaterials, triggerable drug delivery systems and molecular motors.
De novo design of allosterically switchable protein assemblies
Designing nanodevices that can change shape and function in response to molecular signals is a key objective in protein design.
In this talk, Dr. Arvind Pillai. will present recent progress in designing and characterizing a diverse range of switchable protein assemblies. These include protein rings with tunable shape and diameter, cages that disassemble upon peptide binding, and proteins that conditionally form dimers. Notably, these oligomeric systems exhibit allosteric ligand-binding cooperativity on par with, or exceeding, that of natural proteins.
Mass photometry played a critical role in their structural and biophysical analysis, allowing the team to quantify complex features like conditional oligomerization and cooperativity in unprecedented quantitative detail.