MassFerence P2 calibrator for AAV analytics with mass photometry
Refeyn is pleased to announce the expansion of the consumables portfolio for mass photometry. Refeyn has created a new product line of mass reference standards, MassFerence, which help streamline sample characterization with mass photometry.
A fresh look at protein aggregation using mass photometry
Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, both involve an accumulation of protein aggregates [1],[2]. Monitoring and studying small oligomers, which are present in the early stages of disease, can be challenging, due to their transient and heterogeneous nature [1].
Analyze low-affinity interactions with MassFluidix® HC
New microfluidic system enhances protein analysis workflows for the study of weak protein-protein interactions by mass photometry
Refeyn announces appointment of a new CEO
Refeyn, a leading Life Science instrumentation company pioneering mass photometry, announced today that Gerry Mackay has been appointed the new CEO of the company effective January 1st, 2024.
Studying protein oligomerization with mass photometry
Lipoprotein lipase (LPL) has long been a focal point in the study of lipid metabolism. Its role in releasing free fatty acids from triglycerides, allowing their transport across cell membranes, is vital for energy production, while dysregulation of this enzyme has been linked to cardiovascular disease [1].
Overcome analytical bottlenecks with mass photometry
Dr. Martin E. and Dr. Marie A. are experienced scientists – characterizing antibody and gene therapy samples at one of the top 5 pharmaceutical companies. Their lab recently acquired a TwoMP Auto mass photometer and they spoke to us about their initial experience with the instrument and how they are using mass photometry to overcome their analytical challenges.
Exploring the structural dynamics of shelterin with mass photometry
Shelterin is a DNA-binding complex that facilitates telomeric DNA replication and maintenance of telomeric stability 1. Mutations in shelterin components can lead to various pathologies, including cancer predisposition and premature aging.
Mass photometry community comes together in Boston, MA
The mass photometry user meeting took place this year on the US East Coast, bringing together a community of scientists from biopharma and academia to share knowledge and discuss the latest advancements in the field of mass photometry.
Comparing analytical approaches for AAV characterization
AAV sample characterization is a critical step in research, development and manufacturing processes of gene therapies involving these viral vectors (Figure 1). There are several analytical approaches available to assess critical quality attributes (CQAs) for AAV samples, such as capsid content (empty/full ratios) and titer.
Comparing mass photometry and CDMS for AAV analysis
Assessing AAV capsid content is critical for AAV research, development and production. There is an urgent need for reliable techniques that can characterize AAV samples efficiently and accurately, particularly when AAV sample loading shows a high level of heterogeneity [1].
