Mass photometry saves you time and money in cryo-EM experiments
You can never get enough time on an electron microscope. To make the most of the time you do have, you need to streamline the cryo-EM workflow. Negative stain EM (NS-EM) can help you optimize buffer conditions and assess sample quality before you move to the low-temperature microscope, but it’s a time-consuming, expensive technique. What you need is a cost-effective method that can speed up your analysis. The TwoMP, a bioanalytical tool that uses mass photometry to characterize biomolecules, can help you optimize your sample analysis without breaking the bank (or project budget). In this blog, Refeyn product manager Cathryn Langley, DPhil, tells us all about it.
Everything you need to know about analysing AAVs with mass photometry
Ask any AAV researcher – figuring out how many of your capsids are filled and how many are empty is a long and laborious process. There is a clear need to overcome the drawbacks of the current gold-standard analytical methods so users can rapidly and cost-effectively characterise AAVs.
Mass photometry community comes together in Oxford
Mass photometry has reached a new landmark, as the world’s first mass photometry-themed scientific meeting took place on June 14th at the University of Oxford.
Back to BPS: Celebrating four years of mass photometry
Four years ago, at the Biophysical Society’s Annual Meeting 2018 in San Francisco, an early mass photometer made its first public appearance, when a University of Oxford team led by Philipp Kukura and Daniel Cole brought a prototype to demonstrate live in the BPS exhibition hall.
Analyzing complex SARS-CoV-2 samples with mass photometry
The SARS-CoV-2 pandemic has altered our lives and shaped the course of scientific research, bringing an explosion in studies on the virus. Mass photometry has proved valuable in coronavirus research, especially in characterising complex and heterogeneous proteins, and in analysing protein interactions and stoichiometry. In this blog post, we highlight ways that mass photometry has helped investigate previously intractable questions and advance our understanding of SARS-CoV-2.
Refeyn’s new SamuxMP promises to streamline AAV workflows
New compact mass photometer enables rapid analysis of empty/full AAV capsid ratios at the bench
Making sense of mass photometry measurements
Mass photometry is a novel way to measure the mass of biomolecules. It works by quantifying the light scattered by an individual molecule in solution, which is directly proportional to the molecule’s mass [1], [2] (read more about how mass photometry works).
Understanding the strengths and boundaries of mass photometry
Mass photometry is an analytical method that measures molecular mass by quantifying light scattering from individual biomolecules in solution [1]. When considering mass photometry as a new technology for your lab, it is important to understand whether it is suitable for the types of samples you need to analyze.
Here, we describe mass photometry’s mass range, resolution and experimental error, the concentration ranges that can be analyzed, and other information you will find useful as you explore mass photometry.
How does mass photometry work?
Mass photometry is a novel bioanalytical technology that measures molecular mass by quantifying light scattering from individual biomolecules in solution
