Designing nanodevices that can change shape and function in response to molecular signals is a key objective in protein design, paving the way for the development of switchable nanomaterials, triggerable drug-delivery systems, and molecular motors. In this talk, I will present recent progress in designing and characterizing a diverse range of switchable protein assemblies.
Traditional capsid titre methods rely on ELISA which commonly suffers from long turnaround times, low throughput, and large volume sample requirements. This limits the application of ELISA-based methods to routine analysis, thus requiring development of alternative high-throughput (HTP) capsid titre methods. We have performed a comprehensive assessment on currently available orthogonal capsid titre methods using […]
In this 10-minute session, we’ll show you how mass photometry is transforming AAV production with fast, reproducible measurements that use minimal sample at less than $5 per measurement. Mass photometry is also highly user-friendly, with a benchtop instrument that make it perfect for in-house use, cutting reliance on external facilities and boosting research efficiency without […]
This webinar is the second in a series covering our Challenge Themes and the collaborative research projects that are helping us to identify effective solutions to the challenges facing the advanced therapies sector. Here, we will discuss how we are working with a collaborator to drive efficiency of Adeno-Associated Virus (AAV) production and quantification.
In this webinar, Dr. Laura Pala explains how the Karitro MP macro mass photometer measures the size and contrast (related to mass) of viral vectors at the single-particle level, enabling characterization of purity, populations, and physical titer of viral vector samples with speed, accuracy and no need for labels or other sample modification. Through case […]
In this webinar, hear how mass photometry, an easy-to-use bioanalytical technology, can characterize AAV samples in minutes and using little sample. Our expert speaker will also discuss how mass photometry can be readily integrated throughout development and manufacturing.
In this webinar, Dr. Laura Pala will discuss a new technology that enables fast, accurate and label-free analysis of adenovirus (AdV) and lentivirus (LV) samples for cell and gene therapy R&D. This technology – macro mass photometry – characterizes samples of large viral vectors in minutes, at a single-particle level. Dr. Pala will introduce the […]
This webcast will demonstrate harnessing the power of mass photometry to analyze the oligomeric state of the DCAF15–DDA1–DDB1 E3 ligase at low nanomolar concentrations. This study revealed, for the first time, the formation of dimers and trimers with quantified dissociation constants. The oligomeric remodelling effect emphasized the transition from trimer to monomer upon molecular glue […]
Protein ubiquitination is a versatile post-translational modification that orchestrates many cellular pathways. Ubiquitin ligases are key specificity factors in this system. The HECT-type ubiquitin ligase HACE1 controls membrane dynamics and redox homeostasis by mechanisms that are still poorly understood at a structural level.
Join this webinar to learn why mass photometry is an essential technology in the analytical toolbox for the physio-chemical characterization of molecules in multipurpose facilities and labs.
