Discover how this breakthrough technology can deliver fast, accurate biophysical characterization. Join our Mass Photometry 101 webinar to learn the basics, explore diverse applications, and see how it can accelerate your research. You’ll gain valuable insights into: The science behind mass photometry Practical applications, from RNA analysis and antibody stability to biomolecular complex and interaction studies How […]
In this webinar, we will show how we used mass photometry, a single molecule imaging technique capable of detecting biomolecular complexes in solution, to characterize ivonescimab’s binding behaviour with VEGF and PD-1. Join to discover how mass photometry can advance design of the next generation of therapeutic bispecific antibodies, with rapid and quantitative insight into dynamic, […]
This session will highlight new research focused on optimizing AAV6 upstream production – an essential step in improving the safety and affordability of gene therapies. Using a design of experiment (DoE) approach, the Sartorius BIA Separations team systematically identified the optimal conditions to achieve a high full capsid ratio. Further optimization was conducted with the […]
Antibodies remain at the heart of modern therapeutics and diagnostics and the technologies driving their discovery are evolving rapidly. In this webinar, we’ll explore the latest innovations in antibody screening, including next-generation screening, high-throughput platforms and machine learning tools that are accelerating the pace of discovery and development. In addition, leading experts will join us […]
Join us for a webinar to learn how advances in purification techniques have enhanced AAV sample compatibility with mass photometry in upstream development, delivering real-time insights for improved process control and faster decision-making. Attendees will see pre- and post-cleanup case study data provided by Refeyn’s collaborators, Généthon and Rentschler, in addition to mass photometry-supported data […]
Join me to discover how integrating mass photometry into antibody development workflows can drive rapid reliable decision-making. Mass photometry enhances antibody development workflows with insights from: Column-free aggregation assessment in minutes using only nanograms of sample In solution assessment of antibody-antigen binding mechanisms from nM and uM concentration samples Streamlined methodology consisting of only one […]
We will present quantitative results from inhibitor binding studies using mass photometry. Attendees will find out how to implement mass photometry-based workflows for rapid assessment of RNA integrity, enabling faster troubleshooting and quality checks in RNA production or research. Adopting a label-free strategy for monitoring mRNA stability reduces reliance on traditional, time-consuming assays like gel […]
This webinar explores the latest advancements and persistent challenges in AAV-based gene therapy, focusing on analytical testing and manufacturing control. Dr. Anthony Blaszczyk introduces the first USP AAV reference materials, developed to support consistent testing across the gene therapy lifecycle – from raw material qualification to product release. Additionally, Drs. Paul Getty and Lauren Tomlinson […]
In this webinar, we demonstrate how the mass of AAV capsids can be determined using two different novel, emerging single-particle techniques: Charge-detection mass spectrometry (CDMS) and mass photometry. In contrast to ensemble-based approaches (e.g. native mass spectrometry), mass photometry and CDMS can measure the mass of numerous, individual AAV particles, circumventing issues driven by sample […]
Adeno-associated viruses (AAVs) play a crucial role in gene therapy, but producing high-quality vectors at scale remains challenging, particularly due to inefficiencies in DNA packaging. This results in a high proportion of empty or improperly loaded capsids. To address this, Refeyn, Rentschler Biopharma, and the Cell and Gene Therapy Catapult, with support from Innovate UK, […]
