This webinar will also provide updates to the expanding portfolio of consumables and instrument add-ons. You will learn about MassFluidix HC, a microfluidic system which expands the concentration range amenable to mass photometry analysis to micromolar range. This new add-on offers rare insight into how proteins behave at high concentrations, hence allowing to study low […]
In this webinar brought to you by Refeyn, Perla Vega and Philip Kitchen will discuss how to use mass photometry in protein purification workflows, sample characterization prior to cryo-electron microscopy analysis, and G-protein coupled receptor solubilization.
In this webinar, you’ll discover how mass photometry can be used for forced antibody degradation assessment, a crucial aspect of research and development for recombinant mAb therapeutics. Our expert speaker will also demonstrate how mass photometry data compares to and complements the current gold standard, size exclusion chromatography (SEC), as well as providing insights into […]
This webinar aims to showcase the utility of mass photometry in characterizing AAV samples, providing crucial insights for downstream process development. The presentation will highlight the value of mass photometry for characterizing AAV samples during early process development and in accelerating optimization of the polishing step. The examples will demonstrate how mass photometry enables the […]
In this GEN webinar, Dr. Laura Pala will discuss how macro mass photometry enables fast, qualitative analysis of adenovirus and lentivirus samples for cell and gene therapies. She will introduce KaritroMP, a novel analytical instrument that uses macro mass photometry to characterize large viral vectors in research and development environments. During the webinar, she will […]
Join this webinar to discover how a single-molecule technology mass photometry has played a role in the understanding of tau protein aggregation, which is involved in neurodegenerative diseases like Alzheimer’s and Parkinson’s. Learn about the coexistence of native and misfolded conformers and their impact on aggregation kinetics, unlocking new insights into tau aggregation mechanisms. Attend […]
In this webinar, the speaker will describe experiments that uncovered how LPL interacts with its triglyceride substrate and what governs its oligomeric states. Cryogenic electron microscopy (cryoEM) was key to solving the structure of a dimeric LPL oligomer, while mass photometry facilitated a better understanding of LPL dimerization.
This webinar, will explain how the new, compliant software solutions address all regulatory requirements, including user management, audit trails, and signing options when exporting files from Refeyn software applications. The new software solutions will be compatible with the SamuxMP and SamuxMP Auto mass photometers, which are optimized for AAV analytics. This allows the ability to […]
近年バイオ医薬品の開発が目まぐるしく、さらにそのモダリティ開発に関して積極的に取り組まれる中、分子生物学的にそのメカニズムをとらえていく際に蛋白質の挙動を確認していくことは非常に重要である。一方、抗体を代表とする蛋白質治療薬やAAVなどを利用した遺伝子治療薬においては、生物由来の材料を製造していくにあたり、物性的に均一な商品を産生する必要である。ここで示した2例は一見異なるように思えるが、分析化学の観点からみると、蛋白質やその周辺材料のサイズ分布を確認することが必要とされることが示される。今回の発表では、Mass photometry法の特徴を延べ、創薬および製薬分野においてのアプリケーション、特に分子間相互作用解析への応用例、他原理の補完的データ取得についての手法を紹介する。
In this webinar you will learn about the presence of inactive, empty capsids in potentially large quantities is one of the main challenges in AAV production. Quantifying the ratio of empty / full AAV capsids is currently challenging – existing methods are not quick and simple enough to be employed throughout the process.
