In this webinar, Dr. John Zinder, a Senior Scientist in the Structural Biology group at Odyssey Therapeutics, will discuss the purification of shelterin subcomplexes and reconstitution of the entire complex using full-length, recombinant subunits. By combining mass photometry, negative-stain electron microscopy (EM), crosslinking mass spectrometry (XLMS), AlphaFold modelling, and native mass spectrometry (MS), stoichiometries were […]
In the presented analysis, both SEC and mass photometry were used to measure aggregation levels. The results of this short study demonstrate that SEC and mass photometry are complementary, highlighting the usefulness of mass photometry as an orthogonal technique for monitoring aggregation of biopharmaceuticals such as mAbs.
This webcast will demonstrate how the mass of AAV capsids can be determined using two different novel, emerging single-particle techniques: charge-detection mass spectrometry (CDMS) and mass photometry. In contrast to ensemble-based approaches (e.g., native mass spectrometry), mass photometry and CDMS can measure the mass of numerous, individual AAV particles, circumventing issues driven by sample heterogeneity.
Protein polymerization underpins major biological processes, such as cell division and intracellular transport, while undesired assembly can lead to protein aggregates that are associated with, for example, neurodegenerative diseases and cancer.
The webinar will focus on challenges in analytical comparability for gene therapy products. In addition, orthogonal methods along with some of the common statistical analyses will be discussed.
In this webinar, Selgar Henkel-Heinecke (Leipzig University) describes how he and colleagues used mass photometry to determine the composition of this complexmass photometry, to measure the stoichiometry of two miniature Cas12f1 ribonucleoprotein complexes, AsCas12f1 and SpCas12f1 in vitro, as well as their interaction with nucleic acids that are involved in the genome editing process.
This webinar will discuss how mass photometry can be used to characterize AAV capsids and provide vital insights for manufacturing process development. It will also introduce the SamuxMP Auto, Refeyn’s new automated mass photometer.
La photométrie de masse, est une technique bio-analytique dédiée à la caractérisation des molécules. La technologie mesure la masse moléculaire des molécules entre 30 kDa à 5MDa, dans leur états natifs, en solution pour laquelle chaque molécule est détectée et quantifiée.
This webinar brought to you by Refeyn and Luca Schulz will present how using mass photometry can explore the evolution of carbon fixation. Luca Schulz will explain in detail his findings and the role of mass photometry in obtaining them.
In this webinar brought to you by Refeyn, Gareth Rogers will present data on two studies where the automated mass photometer, TwoMP Auto, was used to evaluate the oligomeric status of proteins when subjected to varying experimental conditions, such as varying pH levels or addition of an oligomerization inhibitor.
