mRNA technologies are advancing quickly, supporting new vaccine platforms and emerging therapeutic programs across metabolic, cardiovascular, and oncology research. As development accelerates, understanding mRNA quality, purity, and structural integrity has never been more important. 

During manufacturing and storage, mRNA can form structural variants – such as double-stranded RNA, truncated transcripts, and higher-order multimers – that may reduce translational efficiency, interfere with lipid nanoparticle encapsulation, or affect product safety. Yet many traditional analytical tools rely on denaturing conditions, which limit their ability to reveal these native-state features. 

This on-demand webinar is presented by Professor Mark Dickman from the University of Sheffield who provides an in-depth look at how mass photometry—a label-free, single-molecule technology—enables direct, native-state measurement of mRNA monomers and multimers in solution. Professor Dickman also demonstrates how integrating mass photometry with nondenaturing IP RP HPLC creates a complementary workflow that delivers a far more complete picture of mRNA size, aggregation, and structural integrity.