Structural biology and protein analytics
Characterize proteins and complexes in minutes, at every stage of your structural biology workflow
Accelerate structural biology studies with mass photometry at every step
Structural studies depend on knowing exactly what is in your sample. Mass photometry measures the mass of individual molecules in solution, giving you a direct, quantitative view of sample composition under native conditions. It reveals whether a complex is intact, identifies co-existing species and their stoichiometries, estimates binding affiinities – even for low-affinity interactions – and detects aggregates or impurities that ensemble techniques can miss. Compatible with soluble proteins, membrane proteins, and nucleic acids, it delivers results in minutes using nanograms of sample.
Figure 1. From protein purification to functional analysis, mass photometry delivers rapid, label-free insights at every stage of your structural biology workflow.
Explore applications
Sample purity and optimization
Resolve every protein and complex between 30 kDa and 5 MDa in minutes, with single-molecule resolution. Optimize buffer conditions and confirm sample quality before moving on to expensive and resource-intensive assays.
Protein-protein interactions
Quantify binding stoichiometries, characterize oligomeric states, and measure binding affinities – all in solution, under native conditions, in minutes. Mass photometry gives you a direct, quantitative picture of how your proteins interact.
Membrane protein analytics
Compatible with detergents, amphipols and nanodiscs, mass photometry offers a fast, non-destructive way to optimize purification conditions and characterize membrane proteins. All in minutes, with nanograms of sample.
Sample Spotlight: Protein-nucleic acid interactions
Mass photometry characterizes proteins, nucleic acids, and their interactions in solution under native conditions. With surfaces compatible for both proteins and nucleic acids, you can determine complex stoichiometry, assess sample homogeneity, and detect co-existing species – in minutes with nanograms of sample.
Ready to revolutionize your research?
Find out how mass photometry can transform your sample characterization. Whether you’re focused on drug development, discovery science, or manufacturing, Refeyn’s innovative technology provides the insights you need to accelerate your breakthroughs.
If you have any other questions or would like further details, please get in touch!