Biomolecule Type: Nucleic acids

Therapeutic disruption of RAD52–ssDNA complexation via novel drug-like inhibitors

Ribosome association primes the stringent factor Rel for tRNA-dependent locking in the A-site and activation of (p)ppGpp synthesis

Small-molecule screening of ribonuclease L binders for RNA degradation

Structure of the mini-RNA-guided endonuclease CRISPR-Cas12j3

Single molecule mass photometry of nucleic acids

Homologous chromosomes are stably conjoined for Drosophila male meiosis I by SUM, a multimerized protein assembly with modules for DNA-binding and for separase-mediated dissociation co-opted from cohesin

Cohesin mediates DNA loop extrusion by a “swing and clamp” mechanism

Shelterin is a dimeric complex with extensive structural heterogeneity

A paradigm for regulation at the effector interface with RNA-binding proteins

Mre11-Rad50 oligomerization promotes DNA double-strand break repair