Characterizing the purity of viral vectors such as adenoviruses (AdVs) or lentiviruses (LVVs) for use in cell and gene therapies presents sizeable challenges. Some currently used techniques, like NTA, struggle to resolve all populations in a sample and often fail to detect empty capsids, fragments, and aggregates. Other techniques, like AUC, can resolve different populations, but their high costs, turnaround times, or expertise requirements make them difficult to scale. This opens a need for technologies that can provide key information about the purity of viral vector samples while remaining fast, cost-effective, and user-friendly.    

In this fast-facts session, Jacintha Victoria, Market Development Manager at Refeyn, explains how the KaritroMP macro mass photometer addresses this need via fast, multiparametric, single-molecule analysis of large viral vectors. The strengths of the KaritroMP make it an ideal tool for process development and manufacturing, enabling confident decisions in minutes.