Application Area: Interaction/Binding

Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport

Cohesin mediates DNA loop extrusion by a “swing and clamp” mechanism

Homologous chromosomes are stably conjoined for Drosophila male meiosis I by SUM, a multimerized protein assembly with modules for DNA-binding and for separase-mediated dissociation co-opted from cohesin

Toxin-mediated depletion of nicotinamide dinucleotides drives persister formation in a human pathogen

Denaturing mass photometry for straightforward optimization of protein-protein cross-linking reactions at single-molecule level

Human hnRNPA1 reorganizes telomere-bound Replication Protein A

Structural insights into the mechanism of archaellar rotational switching

Efficient characterization of multiple binding sites of small molecule imaging ligands on amyloid-beta, 4-repeat/full-length tau and alpha-synuclein

A central helical hairpin in SPD-5 enables centrosome strength and assembly

Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR