Mass photometry made fast, simple
Our new MyMass mass photometer delivers fast, accurate assessment of purity and homogeneity so you can move forward with cryo-EM, native MS, SPR or BLI with confidence.
Whether you are an experienced mass photometry user or a newer user looking to learn more, we invite you to join us.
As of May 26th, our consumables pricing has changed, and our catalog has been adjusted to better meet your needs. These updates are based on the valuable feedback you provided in our survey earlier this year.
Thank you for helping us improve!
See single molecules in their native state. No labels required.
Mass photometry measures the mass of individual molecules directly in solution. By detecting tiny changes in light scattering as molecules bind to a glass surface, the technology determines molecular mass with exceptional sensitivity. This label-free approach provides rapid insights into sample purity, interactions, and heterogeneity.
Our technology is transforming research in a wide range of fields.
Precisely characterize AAV preparations by accurately determining empty versus full capsid ratios, aggregation states, and overall integrity. Crucial for optimizing production and ensuring the safety and efficacy of gene therapies.
Gain direct, label-free insights into AdV quality by assessing particle concentration, aggregation, and purity. This enables better control over manufacturing processes for gene delivery vectors and oncolytic agents.
Accurately detect and quantify antibody aggregates in solution – faster and with far less sample than SEC and AUC. Essential for optimizing formulation conditions, improving stability, and ensuring safe, effective biotherapeutics.
Comprehensively profile bispecific and multi-specific antibody-antigen interactions, including stoichiometry. Ideal for new modalities, complements SPR and BLI, aiding experimental design and the interpretation of data on multi-component systems.
Analyze membrane proteins in native-like environments, determining oligomeric states, complex formation, and sample purity. Critical for advancing structural studies, functional assays, and therapeutic development.
Characterize mRNA integrity and its formulation in lipid nanoparticles (LNPs). Assess size distribution, encapsulation efficiency, and stability of mRNA-LNP complexes, vital for developing and quality controlling mRNA-based vaccines and therapies.
Directly measure complex formation, stoichiometry, and binding strength to reveal how proteins interact in solution. Vital for understanding biological mechanisms, validating targets, and accelerating drug discovery.
Our advanced single‑particle analysis reveals population heterogeneity and sample purity. It delivers precise, multiparametric data by simultaneously measuring particle size and mass-related contrast.
For AAV empty/full analysis and more.
We offer a range of mass photometers to suit different applications and budgets. Find the perfect instrument for your lab.
Measure the molecular mass of mRNA, antibodies and other proteins with speed, accuracy, and simplicity. Automated version available.
Check sample purity and homogeneity quickly, easily, and accurately – and run cryo-EM, native MS, SPR, or BLI with confidence.
Rapidly quantify empty, partially filled and full AAV capsids for development and manufacturing. Automated version available.
Gain insights into size, purity and stability to quickly characterize samples of larger viral vectors or virus-like particles.
Use our instrument selector tool to match your application and analysis needs.
See how researchers use mass photometry across real-world applications.
For any biochemical experiments that I will do in the future, I will always use mass photometry as a technique that either complements other techniques or replaces them entirely. I will try to keep mass photometry as integrated in my work as possible because it is a very honest technique that gives you a direct picture of your sample.
Luca Schulz
Max Planck Institute
Our TwoMP is involved in all stages of sample preparation, from initial sample quality assessment to final analysis. It both speeds up our laboratory workflows and improves quality control... We use the TwoMP in every case where analytical SEC would be used normally. We do still utilize this method for sample preparation, but when it comes to analytics, mass photometry is better in both speed and precision.”
Mathias Gschell
BIMOVIS GmbH
From the first moment I saw a mass photometer, I was mind-blown by how simple the instrument was to use and by how quickly you could see individual molecules and complexes... Since mass photometry requires very little sample, it is suitable for proteins that are hard to produce in large quantities... We also use mass photometry to quickly check our samples before using optical tweezers, to make sure we are really measuring single molecules.
Kasia Tych
University of Groningen
Our experience with the KaritroMP has been great - very easy, rapid quantification of empty/full particles in purified adenovirus samples with accuracy comparable to that of AUC.
Shawkat Hussain
University of Oxford
Mass photometry is very straightforward and convenient. You just need to dilute your sample in the right concentration and then you can quickly measure your sample in solution. You can also quickly analyze your measurements.
Eduard Ebberink
Utrecht University
Mass photometry was the method of choice for our study, since it can quickly quantify the relative abundance of all the tau oligomers and show how these populations change over time, from the beginning of the aggregation process.
Simanta Sarani Paul
University of Alberta
Unlike nsEM and cryo-EM, mass photometry allows us to look at our samples at the low nanomolar concentrations we use for activity assays... The MassFluidix HC was able to detect much longer filaments than expected – it turns out they tend to dissociate rapidly upon binding to the surface. We didn’t know our protein could do that!
Lauren Salay
University of Washington
I’ve used AUC, A260/A280 and other techniques to measure adenovirus empty/full capsid ratios. The Karitro lets me do it quickly in the lab, with the accuracy of AUC. What I like most about the Karitro is the speed and ease of us – the software is so simple and straightforward!
Julia Talarek
University of Oxford
[With mass photometry,] we were able to characterize the monomer-to-dimer transition in a low concentration range, which would have been difficult to detect with other techniques... I see mass photometry as a valuable tool in exploring the relationship between enzymatic activity and oligomeric states.
Kathryn Gunn
UNC Chapel Hill
We chose mass photometry for its super-fast turnaround time and minimal sample requirements – compared to methods like AUC. It allows us to rapidly quantify AAV full-to-empty ratios and determine the proportion of AAV particles during purification.
Zhen Shi
AAVnerGene
We had to map the monomer-tetramer equilibrium across concentration, temperature, and time, but other methods couldn't handle the low concentrations or flexible conditions we needed. Mass photometry allowed us to generate this crucial data for the customer and their IND filing.
Michael Skovbo Windahl
Bioneer A/S
In this live webinar, you’ll learn:
Mass photometry operational principles
How the Samux™ mass photometer (SamuxMP) provides serotype-agnostic AAV empty-partial-full-overfull determination
How the SamuxMP benchmarks against legacy methods such as AUC
Discover the insights mass photometry’s single-molecule resolution can reveal – from low-abundance species and detailed purity to complex stoichiometry – that conventional methods like SEC, SDS-PAGE, or DLS simply cannot match.
Curious how mass photometry delivers accurate results – fast? Whether you’re new to the technique or looking to get more from your experiments, our handbook Understanding Mass Photometry is your essential guide.
Curious why mass photometry has been highlighted in over 1,000 scientific publications from leading institutions like GSK, Pfizer, AstraZeneca, Bristol Myers Squibb, Harvard, Columbia, and NIH? Here’s your chance to find out.
Explore Refeyn’s brochure to discover how mass photometry transforms discovery and drug development with rapid, label-free insights into purity, interactions, and vector quality.
Curious how mass photometry delivers accurate results – fast? Whether you’re new to the technique or looking to get more from your experiments, our handbook Understanding Mass Photometry is your essential guide.
Curious why mass photometry has been highlighted in over 1,000 scientific publications from leading institutions like GSK, Pfizer, AstraZeneca, Bristol Myers Squibb, Harvard, Columbia, and NIH? Here’s your chance to find out.
Explore Refeyn’s brochure to discover how mass photometry transforms discovery and drug development with rapid, label-free insights into purity, interactions, and vector quality.
The Refeyn advantage
At the heart of Refeyn’s innovation lies a commitment to providing truly insightful biomolecular data without the traditional trade-offs. Our mass photometry platform is engineered to deliver clear, actionable results quickly and simply, fundamentally changing how you approach characterization.
Originating from the University of Oxford
Read our story ➞
ABL Europe
We’re generating data to compare mass photometry with gold standards like AUC and cryoTEM. Early indications show that it’s much quicker and equally accurate. Partners who’ve compared mass photometry to other methods themselves vouch for its accuracy. It’s a game changer in AAV characterization, for us as well as our clients.
Quentin Bazot
Process Development and Innovation Manager
At Refeyn, our courageous, creative, and caring team is at the heart of our innovation. We are a diverse group of individuals united by a shared passion for accelerating discovery, basic research, drug development, and manufacturing through cutting-edge mass photometry technology. We believe in fostering a collaborative and supportive environment where every team member can thrive and contribute to our mission of challenging the status quo in bioanalytical techniques.
We are constantly growing and looking for talented individuals to join our team. If you are passionate about making a real impact in the world of scientific research and development, we encourage you to explore career opportunities with us.
Find out how mass photometry can transform your sample characterization. Whether you’re focused on drug development, discovery science, or manufacturing, Refeyn’s innovative technology provides the insights you need to accelerate your breakthroughs.
North American Mass Photometry User Day
September 30, 2026 | Hyatt Regency Bethesda, Bethesda, Maryland, 20814, United States
